NYON: Manchester City will face Liverpool in the Champions League quarter-finals.

Liverpool inflicted City’s only Premier League defeat of the season at Anfield on 14 January, after they were thumped 5-0 away in September.

The first leg is at Anfield on 4 April, with the return on 10 April.

City director of football Txiki Begiristain said: “It’s going to be a great couple of games.” Liverpool boss Jurgen Klopp added: “I saw his face. He didn’t look like it was Christmas.”

Holders Real Madrid will face Italian champions Juventus – a repeat of the 2017 final which Real won 4-1 in Cardiff.

La Liga leaders Barcelona, who are looking to win the Champions League for the first time since 2015, face Roma.

Sevilla, who beat Manchester United 2-1 on aggregate in the previous round, take on five-time European champions Bayern Munich.

The tie between Liverpool and City will be the first meeting between Premier League sides in the Champions League quarter-finals since 2010-11, when Chelsea faced Manchester United.

On that occasion, United advanced 3-1 on aggregate on their way to the final, which they lost by the same scoreline to Barcelona at Wembley.

City are 21 points clear of fourth-placed Liverpool in the table – and they are the top two scorers in the Premier League.

City have scored 85 times in 30 games while Liverpool have netted 68 in the same number of matches.

“I knew it would be difficult and that is difficult,” said Klopp when asked about the draw on Friday.

“The good news is for Manchester City it will be difficult as well.

“We are for sure not the favourites in this round, but in the last eight there are not a lot of favourites – maybe two of them, Bayern and Barcelona.”

While Liverpool have been crowned champions of Europe five times, City are chasing their first Champions League success.

“It’s a very difficult one,” said Begiristain.

“We like to travel and to go to another country in the Champions League, but it is what it is.

“In the Champions League there is no time for mistakes, everything has to work, you have to be almost perfect in both games.

“We know the power and the strength of Liverpool.”

Both City and Liverpool face big derby matches in the Premier League between the first and second legs.

City host Manchester United on Saturday, 7 April at 17:30 BST, five hours after Liverpool visit Everton for a 12:30 kick-off.

“I know countries where they cancel whole match days so teams can be in the best shape,” said Klopp.

“We play Wednesday night against Manchester City, and then play Everton at 12:30 three days later.

“That’s not too cool but obviously we have to go the hard way, I am used to that. We take it like it is.

“If I cannot be angry about something like that anymore and have to be politically correct and say nothing then I am dead because that doesn’t work.”

City could be champions of the Premier League by the time they host Liverpool in the second leg.

The full draw

Barcelona v Roma

Sevilla v Bayern Munich

Juventus v Real Madrid

Liverpool v Manchester City

Political complication

Arsenal have been drawn against Russian side CSKA Moscow in the Europa League quarter-finals at  a delicate diplomatic time amid the controversy over the nerve agent attack on a former Russian spy in England.

The Gunners will host the first leg at Emirates Stadium on 5 April with the return game in Moscow a week later.

Arsenal beat AC Milan 3-1 on Thursday, for a 5-1 aggregate win, to reach their first European quarter-final since 2010.

They are 12 points adrift of fourth place in the Premier League and winning the Europa League appears to be their best chance of qualifying for next season’s Champions League.

On Wednesday, the Foreign Office updated its advice for those visiting Russia, saying UK nationals in the country should be “aware of the possibility of anti-British sentiment or harassment”.

It said the British Embassy in Moscow was “not aware of any increased difficulties for British people travelling in Russia at this time” but recommended UK nationals “remain vigilant, avoid any protests or demonstrations and avoid commenting publicly on political developments”.

CSKA dropped into the Europa League after finishing third in their Champions League group behind Manchester United and Swiss club Basel.

The team, which includes several Russia players, are third in the Russian Premier League.

Their star men include attacking midfielder Alan Dzagoev and goalkeeper Igor Akinfeev, who in November kept his first Champions League clean sheet for more than 11 years – a run of 43 games.

On-loan Leicester City striker Ahmed Musa is also in the squad.

CSKA are one of only five teams Arsene Wenger has faced more than once as Arsenal boss and failed to win against. Fiorentina, PAOK Salonika, Paris St-Germain and Port Vale are the others.

Europa League draw

RB Leipzig v Marseille

Arsenal v CSKA Moscow

Atletico Madrid v Sporting Lisbon

Lazio v Red Bull Salzburg